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Cat No. | Product Name | Synonyms | Targets |
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T76704 | Tralokinumab | CAT-354,LP 0162 | IL Receptor |
Tralokinumab is a fully human IgG4 monoclonal antibody with a high affinity for IL-13 alone. Tralokinumab's potential anti-inflammatory activity prevents IL-13 receptor interaction and subsequent downstream signaling and... | |||
T76773 | Rolinsatamab | IL Receptor | |
Rolinsatamab is a fully humanized selective monoclonal antibody that is a potent dual inhibitor of IL-4 and IL-13. Rolinsatamab chimeric antigen receptor sequence T cells. Rolinsatamab can be used to prevent and treat im... | |||
T36527 | IL-4-inhibitor-1 | IL Receptor | |
IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhib... | |||
T76896 | Abrezekimab | UCB4144,VR 942 | IL Receptor |
Abrezekimab (VR 942) is composed of CDP7766, leucine, and trehalose. Abrezekimab is a humanized antibody that targets human IL-13. Abrezekimab inhibits binding to IL-13Rα1 subunit. Abrezekimab can be used to study biolog... | |||
T13666 | Dupilumab | REGN-668,SAR-231893 | IL Receptor |
Dupilumab (REGN-668) is a systemic immunomodulator for AD. Dupilumab is a fully human monoclonal antibody against the alpha subunit of the interleukin-4 receptor, which inhibits downstream signaling of IL-4 and IL-13 and... | |||
T5416 | T-5224 | MMP | |
T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. | |||
T80610 | Romilkimab | SAR156597 | |
Romilkimab (SAR156597) is a chimeric humanized immunoglobulin (Ig) antibody designed to specifically target interleukins 4 and 13 (IL-4 and IL-13) [1]. | |||
T9901A-011 | Lunsekimig | SAR443765 | |
Lunsekimig (SAR443765) is an IL-13/TSLP bis-antibody that links a nano-antibody targeting IL-13 and a variable region of the heavy chain (VHH) targeting TSLP for use in asthma research. | |||
T76942 | Cendakimab | ||
Cendakimab (RPC4046; ABT 308; CC-93538) is a selective humanized recombinant monoclonal antibody targeting the IL-13 molecule with high specificity. It demonstrates potent affinity for both the wild-type and variant form... | |||
T70001 | Pyrazinib | ||
Pyrazinib is a novel inhibitor of angiogenesis and metabolism of oesophageal adenocarcinoma (oac) radioresistance, significantly inhibiting the secretion of il-6, il-4, il-8 and il-13 cytokines from in oac radioresist... | |||
T81098 | Stapokibart | CM310 | |
Stapokibart (CM310), a humanized monoclonal antibody, selectively binds to IL-4Rα, inhibiting the cytokines IL-4 and IL-13 from interacting with their shared co-receptor subunit, IL-4Rα. This compound demonstrates cross-... | |||
T76686 | Lebrikizumab | ||
Lebrikizumab, an IgG4 humanized monoclonal antibody, specifically targets and inhibits interleukin-13 (IL-13), thus impacting its function. This compound is utilized in asthma research [1]. | |||
T60921 | PF-07038124 | ||
PF-07038124 is an inhibitor of PDE4. The IC50 value of PF-07038124 for PDE4B2 is 0.5 nM. PF-07038124 shows inhibitory activities against IFNγ, IL4, and IL-13 with IC50 values of 1.06, 4.1, and 125 nM, respectively [1]. | |||
T73018 | NLRP3-IN-13 | ||
NLRP3-IN-13 is a selective and potent inhibitor of NLRP3 (IC 50: 2.1 μM), capable of inhibiting both NLRP3 and NLRC4 inflammasomes as well as NLRP3-mediated IL-1β production. Furthermore, NLRP3-IN-13 suppresses NLRP3 ATP... | |||
T80599 | Dectrekumab | QAX576 | |
Dectrekumab (QAX576), a humanized monoclonal antibody targeting IL-13, significantly reduces intraepithelial esophageal eosinophil counts and normalizes dysregulated esophageal disease-related transcripts in Eosinophilic... | |||
T76906 | Anrukinzumab | ||
Anrukinzumab (IMA-638), a humanized anti-IL-13 monoclonal antibody, effectively reduces lung inflammation in cynomolgus monkeys and shows potential in the studies of ulcerative colitis (UC) and asthma [1] [2] [3]. | |||
T36623 | Antileukinate | ||
Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutro... | |||
T81314 | Rademikibart | CBP-201 | |
Rademikibart (CBP-201) is a human monoclonal antibody selective for IL-4Rα, exhibiting strong affinity with a KD of 20.7 pM for human IL-4Rα epitopes, without cross-reactivity to IL-4Rα from other species. It effectively... | |||
T71143 | Ambroxol-d5 | ||
Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine. It decreases short-circuit currents in electrica... | |||
T37564 | C4 Ceramide (d18:1/4:0) | C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0) | |
C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used... | |||
T36320 | C6 L-threo Ceramide (d18:1/6:0) | C6 L-threo Ceramide (d18:1/6:0) | |
C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 L-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlik... | |||
T36998 | 7β,27-dihydroxy Cholesterol | 7β,27-DHC,7β,27-dihydroxy Cholesterol | |
7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, res... | |||
T37565 | C6 D-threo Ceramide (d18:1/6:0) | C6 D-threo Ceramide (d18:1/6:0) | |
C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlik... | |||
T35927 | C2 L-threo Ceramide (d18:1/2:0) | C2 L-threo Ceramide (d18:1/2:0) | |
C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration o... | |||
T71933 | GNE-3500 | ||
GNE-3500 is a Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inverse Agonist. Retinoic acid receptor-related orphan receptor C (RORc, RORγ, or NR1F3) is a nucle... | |||
T35864 | T-5342126 | ||
T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50= 27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isola... | |||
T35406 | α-MSH TFA | ||
α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocyt... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1189 | 13-Methylberberine chloride | 13-Methylberberine | Others |
13-Methylberberine chloride shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug | |||
T35741 | Gliovirin | ||
Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the pa... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03123 | IL-13 Protein, Mouse, Recombinant | Mouse | HEK293 Cells |
IL-13 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.35 kDa and the accession number is P20109. | |||
TMPJ-00596 | IL-13 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
IL-13 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 38-60 KDa and the accession number is AAK53823. | |||
TMPY-01993 | IL-13 Protein, Human, Recombinant | Human | CHO Cells |
IL-13 Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.5 kDa and the accession number is AAK53823.1. | |||
TMPJ-00575 | IL-13 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
IL-13 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 13-30 KDa and the accession number is AAH96139. | |||
TMPY-00840 | IL-13 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
IL-13 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39 kDa and the accession number is AAK53823.1. | |||
TMPJ-00890 | IL-13 Protein, Mouse, Recombinant (aa 26-131, His) | Mouse | HEK293 Cells |
IL-13 Protein, Mouse, Recombinant (aa 26-131, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 15-30 KDa and the accession number is P20109. | |||
TMPJ-00889 | IL-13 Protein, Mouse, Recombinant (aa 22-131, His) | Mouse | HEK293 Cells |
IL-13 Protein, Mouse, Recombinant (aa 22-131, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 14-30 KDa and the accession number is P20109. | |||
TMPY-00982 | IL-13 Protein, Cynomolgus, Recombinant | Cynomolgus | HEK293 Cells |
IL-13 Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.3 kDa and the accession number is Q0PW92. | |||
TMPJ-00594 | IL-13 Protein, Human, Recombinant (Avi & His), Biotinylated | Human | HEK293 Cells |
IL-13 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 22-35 KDa and the accession number is AAK53823. | |||
TMPY-01258 | IL-13RA1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
IL-13RA1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.3 kDa and the accession number is P78552-1. | |||
TMPY-00841 | IL-13RA2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
IL-13RA2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q14627. | |||
TMPK-00617 | IL-13 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast ce... | |||
TMPY-01170 | IL-13RA1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
IL-13RA1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.6 kDa and the accession number is O09030. | |||
TMPK-00244 | IL-13RA2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha,... | |||
TMPK-00243 | IL-13Ra2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha,... | |||
TMPK-00273 | IL-13Ra1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha,... | |||
TMPK-00272 | IL-13RA1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha,... | |||
TMPH-00493 | IL-13 Protein, Canine, Recombinant (His) | Canine | E. coli |
IL-13 Protein, Canine, Recombinant (His) is expressed in E. coli. | |||
TMPY-02136 | IL-13 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
IL-13 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.5 kDa and the accession number is Q0PW92. | |||
TMPY-06579 | IL-13RA1 Protein, Human, Recombinant(aa 1-343, His & Avi), Biotinylated | Human | HEK293 Cells |
IL-13RA1 Protein, Human, Recombinant(aa 1-343, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 40.15 kDa and the accession number is NP_001551.1. | |||
TMPY-01074 | IL-13RA1 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
IL-13RA1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 65 kDa and the accession number is P78552-1. | |||
TMPY-05123 | IL-13RA1 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
IL-13RA1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.3 kDa and the accession number is P78552-1. | |||
TMPY-06590 | IL-13RA1 Protein, Human, Recombinant (aa 1-343, hFc) | Human | HEK293 Cells |
IL-13RA1 Protein, Human, Recombinant (aa 1-343, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 63.62 kDa and the accession number is NP_001551.1. | |||
TMPY-05334 | IL-13RA2 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
IL-13RA2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q14627. | |||
TMPY-00842 | IL-13RA2 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
IL-13RA2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 65 kDa and the accession number is Q14627. | |||
TMPH-00551 | IL-13 Protein, Equus caballus, Recombinant (His) | Horse | P. pastoris (Yeast) |
IL-13 Protein, Equus caballus, Recombinant (His) is expressed in Yeast. | |||
TMPY-05432 | IL-13RA1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
IL-13RA1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.8 kDa and the accession number is O09030. | |||
TMPY-05795 | IL-13RA1 Protein, Mouse, Recombinant (mFc) | Mouse | HEK293 Cells |
IL-13RA1 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 62.41 kDa and the accession number is O09030. | |||
TMPJ-00270 | IL-13RA1 Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 Cells |
Interleukin-13 receptor subunit alpha-1(IL-13RA1), also known as NR4, belongs to the hemopoietin receptor family. Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. It interacts with TR... | |||
TMPJ-01210 | IL-33 Protein, Mouse, Recombinant | Mouse | E. coli |
Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identifi... | |||
TMPY-06981 | IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli) | Human | E. coli |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli... | |||
TMPJ-00387 | IL-4R alpha Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions a... | |||
TMPY-02869 | MMP-12 Protein, Human, Recombinant (catalytic domain) | Human | E. coli |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ... | |||
TMPY-02790 | IL-4 Protein, Canine, Recombinant | Canine | E. coli |
IL-4 Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13 kDa and the accession number is O77762. | |||
TMPK-00035 | IL-4 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Interleukin-4, also known as IL4, is a secreted protein which belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation.In t... | |||
TMPK-00919 | IL-4 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Interleukin-4, also known as IL4, is a secreted protein which belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation.In t... | |||
TMPK-00034 | IL-4 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
Interleukin-4, also known as IL4, is a secreted protein which belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation.In t... | |||
TMPY-05353 | CCL26 Protein, Human, Recombinant | Human | Baculovirus Insect Cells |
The eotaxin subfamily of CC chemokines consists of eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. All eotaxins induce the trafficking of eosinophils to the sites of inflammation via CC chemokine receptor 3 (CCR3),... | |||
TMPJ-01056 | IL-18 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Interleukin-18 (IL-18)is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63... | |||
TMPH-03267 | CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO) | Rat | E. coli |
Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which... | |||
TMPH-03116 | IL-4R Protein, Pig, Recombinant (His) | Sus scrofa (Pig) | E. coli |
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production a... | |||
TMPH-03266 | CHI3L1 Protein, Rat, Recombinant (His) | Rat | E. coli |
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a rol... | |||
TMPK-01391 | Fibronectin Protein, Human, Recombinant (aa 1266-1356, His) | Human | HEK293 Cells |
Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells ... | |||
TMPK-01373 | Fibronectin Protein, Human, Recombinant (aa 1266-1356, hFc) | Human | HEK293 Cells |
Fibronectin is a high molecular glycoprotein present in the blood, connective tissue and at cell surface. It is synthesized by many types of differentiated cells and is believed to be involved in the attachment of cells ... |